Cortisol, Blood


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Quest Diagnostics Test Code: 367

Cortisol is a hormone that is secreted from the adrenal glands in a diurnal rhythm of secretion, meaning it levels peak around the same time in the morning and decreases as the day progresses. This hormone is plays a big role in multiple important bodily functions, such as in the metabolism of lipids, carbohydrates and proteins, the regulation of blood glucose and blood pressure and well as maintenance and regulation of the immune system. Cortisol tests are used to for the diagnosis of Cushings disease, which is too much cortisol, or Addisons disease, which is too little cortisol. Cortisol can be tested in multiple ways. This is simply a random cortisol blood test at any time of the day, but time should be noted when sending the blood away.

This test is performed in following conditions such as:

• Hypertension (Cushings)
• High blood sugar
• Obesity
• Purple streaks on the abdomen
• Muscle wasting and weakness
• Osteoporosis
• Weight loss
• Fatigue
• Low blood pressure (Addisons)
• Abdominal pain
• Dark patches of skin

Also Known As: Compound F, Hydrocortisone


People ordering this test must acquire a specimen collection kit at the lab prior to making a collection. Saliva should be collected at the time(s) recommended by your doctor. No food or fluids for 30 minutes prior to collection. Do not use any creams, lotions, or steroid inhalers immediately prior to collection. Avoid any activity that can cause your gums to bleed, including brushing and flossing your teeth. Consult with your doctor if this is a chronic problem. Do not use this kit on anyone with increased risk of swallowing or choking.


Specimen Collected
  • Blood
Estimated Time Taken

Turnaround time for the Cortisol blood test is typically 2-3 business days.